361 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
By optimizing human lung slices, researchers discovered that idiopathic pulmonary fibrosis is driven by alveolar type 2 cells trapped in a biophysically dysfunctional, migratory transition state caused by imbalanced developmental repair programs, specifically linking persistent -catenin activation to long-term tissue remodeling.
Calorie restriction delays the onset of autoimmune diabetes in NOD mice by inducing a post-mitotic, PD-L1-high beta cell state that remodels the islet microenvironment into a pro-tolerogenic state, thereby reducing immune-mediated beta cell destruction.
This study reports the first detection of histone H3 Ser10 phosphorylation in *Trypanosoma cruzi*, demonstrating that this novel epigenetic mark is exclusively present in replicative stages and peaks during the G2/M phase of the cell cycle.
This study demonstrates that in the animal relative *Sphaeroforma arctica*, microtubules work alongside actin networks to guide membrane furrows and ensure the faithful partitioning of nuclei and cytoplasm during cellularization, revealing conserved mechanistic parallels with canonical cytokinesis.
This study reveals that in yeast, the AP-3 adaptor complex and V-ATPase spatially associate with CTP synthase (Ura7) at the vacuole to coordinately regulate its assembly dynamics, where AP-3 promotes filament formation while restraining elongation, and V-ATPase inhibition triggers massive cytoophidia assembly in response to vacuolar function.
This study demonstrates that PEX11{beta} deficiency in human iPSC-derived neural progenitors disrupts peroxisomal fission and ether-linked phospholipid synthesis, leading to altered neurodevelopmental phenotypes such as increased neural rosette lumen size and progenitor numbers, despite sparing mitochondrial function.
This study demonstrates that a closed-loop cell therapy, engineered to autonomously secrete an Activin A inhibitor (ActR2A-Fc) in response to Activin A exposure via a BMP-responsive promoter, effectively prevents heterotopic bone formation in a mouse model of fibrodysplasia ossificans progressiva (FOP).
This study identifies the ATP8B1-TMEM30B flippase complex as essential for maintaining phosphatidylserine asymmetry in outer hair cell stereocilia, a process critical for hearing that is disrupted by TMC1/2 scramblase activity and whose failure leads to rapid hair cell degeneration and deafness.
This paper identifies a specific splice variant of PMCA2 that localizes to the lysosome to form a complex with NPC1, a mechanism essential for lysosomal calcium homeostasis and a shared pathological link between Niemann-Pick disease type C and Parkinson's disease.
The paper proposes a new model suggesting that cholesterol distribution between the two leaflets of the plasma membrane is determined by stoichiometric complexation with phospholipids rather than lipid affinity, predicting a 2:1 exofacial-to-endofacial ratio in human erythrocytes.