416 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study establishes Protease-Activated Receptor 1 (PAR1) as an endogenous model of functional selectivity, demonstrating that thrombin and activated protein C cleavage differentially engage Gq and G12 signaling pathways to drive distinct physiological outcomes, such as platelet activation versus cytoprotection, without recruiting β-arrestin.
This study reveals that endosome motility and peroxisome hitchhiking in *Aspergillus* fungi are critical regulators of light-responsive developmental decisions and the biosynthesis of secondary metabolites, including carcinogenic mycotoxins.
This study demonstrates that activating the lysosomal channel TPC2 specifically amplifies calcium transfer to mitochondria via an ER-dependent relay, thereby modulating cellular energy resilience and influencing stroke outcomes through a balance between enhanced oxidative phosphorylation and susceptibility to calcium-induced damage.
This study establishes a versatile toolkit of fluorescent markers for live-cell imaging of ten major organelles in *Cryptococcus neoformans*, revealing condition- and stage-specific subcellular remodeling that supports investigations into fungal adaptation, development, and virulence.
This study demonstrates that restoring epidermal homeostasis, particularly through the normalization of differentiated keratinocyte lipid and barrier programs, actively drives the resolution of chronic skin inflammation by reorganizing transcriptional networks and suppressing immune responses.
This study utilizes volume electron microscopy to reveal the 3D ultrastructure of *C. elegans* gut granules as endoderm-restricted, bi-lobed organelles featuring a tubular ring surrounding a membrane-bound compartment with a dense particle, thereby providing detailed structural evidence for their dual-compartment organization.
This study demonstrates that macrophage-based assays, specifically utilizing U937 cells for polarization studies and RAW264.7 cells for routine screening, serve as effective and standardized in vitro tools for evaluating the anti-inflammatory potency of mesenchymal stem cell products.
This study reveals that the essential Drosophila gene *mute* ensures genome stability by repressing histone mRNA accumulation outside of S phase through counteracting Cyclin E/Cdk2-dependent activation, while simultaneously promoting specific histone expression during S phase, with its loss leading to widespread transcriptomic changes and developmental defects.
This study reveals that Derlin-mediated ERAD prevents the accumulation of the lipid regulator ORMDL3 at ER-mitochondria contact sites, thereby safeguarding mitochondrial function and linking ERAD-dependent spatial control to the pathogenesis of numerous human diseases.
This study reveals that medulloblastoma-associated mutations in the E3 ligase adaptor KBTBD4 cause a dual pathological effect by gaining the ability to degrade transcriptional repressors while simultaneously losing the critical function of degrading free PP2A-A scaffolding subunits, thereby disrupting phosphatase quality control and dysregulating key cancer signaling pathways.